Technology
Immobilization Engineering™ unlocks the power of your enzyme
To use cell-free biocatalysts at scale requires enzyme immobilization.
The approach
Everything starts with your enzyme
Everything starts with the enzyme, and every enzyme is unique. Differences in homology and structure tell us that it’s impossible to apply a one-size-fits all approach to immobilization. That’s why we built general purpose tools to quickly navigate the relevant multi-factor design landscape for enzyme immobilization.
Lab consumables
Predictive Immobilization Plates (PIPs)
FabricNano has built the first statistically-guided approach to immobilization where the relevant factor space is spanned in a simple 96-deep well plate. The benefit of 1,000,000 combinatorial options are collapsed to a set of 96 experiments, all pre-prepared in deep well plate format to help speed up research in the lab.
Service offering
PIP-Predict
FabricNano applies our Design of Experiments (DoE) model to the data collected from use of a PIP. The combined approach of collecting PIP data and applying DoE means that we learn enough in 96 wells to predict the optimal immobilization protocol in silico from the 1 million datapoints you didn’t have to screen.
Service offering
Interaction Engineering™
FabricNano has taken the concept of sequence-to-function for active site mutagenesis and applied the same principles to sequence-to-immobilization performance. The surface mutagenesis strategy leverages proprietary dataset generated on the first ever high-throughput automated workcell dedicated to studying immobilization. Private and secure servers run our LLM models, so that your confidential IP stays safe.
