A sustainable future,
powered by enzymes
Early 2000s: Cell-based technology
Startups spent billions to genetically engineer living organisms; yeast, fungi, and E coli
Living organisms are inefficient, slow and unpredictable to scale. Whereas the enzyme machinery inside is efficient, fast and scalable.
State-of-the-art: Cell-free technology
Enzymes are the fundamental machinery of biology
And every machine needs to be built robustly. Every enzyme needs to withstand industrial process conditions. This requires a new toolset that is critical to commercial success.
What is Immobilization Engineering™
Engineering enzymes to perform when immobilized
Immobilization has been used for decades to stabilize enzymes at the expense of activity. The approach has always been random and the result lacking a statistical directionality. FabricNano brings a first-of-its-kind statistical and engineering approach: Immobilization Engineering™. Now you get enzyme stability and enhanced performance too.
What are Predictive Immobilization (PI) plates?
Millions of datapoints in a single 96 well plate
Immobilization materials are typically sold with one generic "protein purification" protocol. To develop an enzyme-specific "performance protocol" is not only tedious and laborious, but where do you even start? PI plates are designed to exhaust the vast protocol design space in a stastically guided way, and better yet, each of the 96 wells has already been prepared to accelerate your time in the lab
What is Interaction Engineering™ service?
Enzyme surface mutations to unleash the true power of immobilization
Our proprietary datasets study enzymes being immobilized on different materials under the influence of various mixing protocols. With best-in-class immobilization, we then embark on a directed mutagenesis strategy targeting enzyme surface featurization. We are only scratching the surface of the potential of Interaction Engineering™ to boost enzyme performance.
Can this have impact today?
Materials and protocols are ready for scale. Let us work on your enzyme.
Immobilization Engineering™ takes material access into account from day 1. We partner with our material suppliers to ensure you have prolonged access to your immobilization material at the best rates in the business. We discover enzyme-specific immobilization protocols that cannot be found elsewhere.